2025
Effects of the (Trialkyl)ammonium Structures in (Ammonio)amidyl Groups on π-Electron Donating Ability and Thermal Stability: Experimental and Computational Study
Hikaru Fujita, Takanari Arai, Hiroki Muraya, Yoshika Matsuyama, Munetaka Kunishima
Chemical and Pharmaceutical Bulletin 2025, 73 (8), 752–761 (DOI: 10.1248/cpb.c25-00260)
Selective Modification of Carboxylic Acids with Oximoyl Chlorides under Aqueous Conditions
Kaho Hyakunari, Koki Imai, Kenji Mishiro
Organic Letters 2025, 27 (26), 7206–7211 (DOI: 10.1021/acs.orglett.5c02152)
Light-Induced Conjugation of Inorganic Phosphate and Sulfate with Aminocyclobutenediones under Aqueous Conditions
Koki Ogawa, Rena Kobayashi, Nanami Okada, Kenji Mishiro
Chemistry–A European Journal 2025, 31 (23), e202500187 (DOI: 10.1002/chem.202500187)
2024
Development of a Triazinyluronium-Based Dehydrative Condensing Reagent with No Heteroatomic Bonds
Gaku Mizushima, Hikaru Fujita, Munetaka Kunishima
The Journal of Organic Chemistry 2024, 89 (24), 18660–18664 (DOI: 10.1021/acs.joc.4c02075)
Alkoxy Exchange Strategy for the Synthesis of N,N′-Dimethylated (Alkoxy)triazinediones as Solid Reagents for Acid-Catalyzed O-Alkylation
Hikaru Fujita, Tomomi Yagitani, Munetaka Kunishima
The Journal of Organic Chemistry 2024, 89 (20), 15302–15306 (DOI: 10.1021/acs.joc.4c01406)
Bicyclic-Ammonium-Incorporated Ylidic Nitrogen Groups for Strong π-Electron Donation in Push–Pull Benzene π-Conjugated Systems
Hikaru Fujita, Takanari Arai, Naoto Kuchiki, Munetaka Kunishima
Organic Letters 2024, 26 (35), 7313−7317 (DOI: 10.1021/acs.orglett.4c02378)
Phototriggered Generation of Ynol Ethers and Their Rearrangement to Ketenes
Shunsuke Mogami, Masanobu Baba, Taniyuki Furuyama, Munetaka Kunishima, Kenji Mishiro
The Journal of Organic Chemistry 2024, 89 (15), 10709−10718 (DOI: 10.1021/acs.joc.4c00947)
Development of a Purely Isolable (Dimorpholino)triazine-Based Reagent for the Epoxidation of Alkenes
Hikaru Fujita, Toshiyuki Kato, Tatsuki Betsuyaku, Munetaka Kunishima
Synlett 2024, 35, in press (DOI: 10.1055/a-2356-8451)
Carbocationoids, a concept for controlling highly reactive cationic species
Hikaru Fujita, Daichi Shimada, Jotaro Kudo, Kazuyuki Kosha, Satoshi Kakuyama, Hiromitsu Terasaki, Munetaka Kunishima
Communications Chemistry 2024, 7, 55 (DOI: 10.1038/s42004-024-01139-w)
Drug–drug conjugates of MEK and Akt inhibitors for RAS-mutant cancers
Hikaru Fujita, Sachiko Arai, Hiroshi Arakawa, Kana Hamamoto, Toshiyuki Kato, Tsubasa Arai, Nanaka Nitta, Kazuki Hotta, Natsuko Hosokawa, Takako Ohbayashi, Chiaki Takahashi, Yasuhide Inokuma, Ikumi Tamai, Seiji Yano, Munetaka Kunishima, Yoshihiro Watanabe
Bioorganic & Medicinal Chemistry 2024, 102, 117674 (DOI: 10.1016/j.bmc.2024.117674)
Phototriggered Butenolide Formation from a Cyclobutenedione and an Acidic Nucleophile
Kenji Mishiro, Aiko Sesumi, Takanori Fujii, Taniyuki Furuyama, Munetaka Kunishima
Organic Letters 2024, 26 (1), 380-384 (DOI: 10.1021/acs.orglett.3c04054)
2023
Epitope-Based Specific Antibody Modifications
Saki Horie, Kenji Mishiro, Mio Nishino, Inori Domae, Mitsuo Wakasugi, Tsukasa Matsunaga, Munetaka Kunishima
Bioconjugate Chemistry 2023, 34 (11), 2022–2033 (DOI: 10.1021/acs.bioconjchem.3c00340)
Hydrophobic-Substrate-Selective Dehydrative Condensations at the Emulsion Interface under Conditions where Competitive Reactions Proceed in the Bulk Aqueous Phase
Takuya Matsumoto, Eri Hirata, Hanlin Zhang, Kazuhito Hioki, Munetaka Kunishima
Asian Journal of Organic Chemistry 2023, 12 (1), e202200602 (DOI: 10.1002/ajoc.202200602)
2022
Synthesis and characterization of tetraphenylammonium salts
Hikaru Fujita, Ozora Sasamoto, Shiori Kobayashi, Masanori Kitamura, Munetaka Kunishima
Nature Communications 2022, 13, 2537 (DOI: 10.1038/s41467-022-30282-y)
Science誌のResearch Highlightsに選ばれました！
Chem-Stationのスポットライトリサーチ(紹介ムービー付き)で紹介されました！
金沢大学プレスリリースに掲載されました！
Nucleophilic substitution reactions of unbranched alkyl amines using triazine reagents
Masanori Kitamura, Yuki Kitaoka, Hikaru Fujita, Munetaka Kunishima
Tetrahedron Letters 2022, 93, 153692 (DOI: 10.1016/j.tetlet.2022.153692)
Synthesis of N-Aminated Salts of Aliphatic tert-Amines, (Trialkyl)amidines, and (Pentaalkyl)guanidines by Electrophilic Amination in an Ethereal Solvent
Hikaru Fujita, Takanari Arai, Munetaka Kunishima
Chemical and Pharmaceutical Bulletin 2022, 70(1), 85-88 (DOI:10.1248/cpb.c21-00673)
2021
Conjugation of 4-(dimethylamino)pyridine to primary amines in aqueous buffer solutions using an N-hydroxysuccinimide ester reagent
Saki Horie, Hikaru Fujita, Rina Yamashita, Munetaka Kunishima
Tetrahedron Letters 2021, 81(28), 153343 (DOI: 10.1016/j.tetlet.2021.153343)
Development of a triazinedione-based dehydrative condensing reagent containing 4-(dimethylamino)pyridine as an acyl transfer catalyst
Jie Liu, Hikaru Fujita, Masanori Kitamura, Daichi Shimada, Munetaka Kunishima
Organic & Biomolecular Chemistry 2021, 19(21), 4712–4719 (DOI:10.1039/D1OB00450F)
A versatile iodo(III)etherification of terminal ethynylsilanes using BF3-OiPr2 and alkyl benzyl ethers
Takuya Matsumoto, Hiroshi Hagiyama, Kanetsugu Kuribayashi, Kazuhito Hioki, Hikaru Fujita, Masahito Ochiai, Munetaka Kunishima
Organic & Biomolecular Chemistry 2021, 19(17), 3825–3828 (DOI: 10.1039/D1OB00479D)
Efficiency Enhancement of a Photocatalytic Decarbonylation of an Aminocyclopropenone by Benzothiophene Substitution
Kenji Mishiro, Mitsuki Nomura, Taniyuki Furuyama, Munetaka Kunishima
The Journal of Organic Chemistry 2021, 86 (4), 3625–3636 (DOI: 10.1021/acs.joc.0c02997)
2019
Development of Triazinone-Based Condensing Reagents for Amide Formation
Kohei Yamada, Mika Kota, Kensuke Takahashi, Hikaru Fujita, Masanori Kitamura, Munetaka Kunishima
The Journal of Organic Chemistry 2019, 84 (23), 15042–15051 (DOI:10.1021/acs.joc.9b01261)
Substitution of the Dimethylamino Group in Gramines and One-Pot Cyclization to Tetrahydro-β-carbolines Using a Triazine-Based Activating Agent
Hikaru Fujita, Riho Nishikawa, Ozora Sasamoto, Masanori Kitamura, Munetaka Kunishima
The Journal of Organic Chemistry 2019, 84 (13), 8380–8391 (DOI: 10.1021/acs.joc.9b00039)
Preparation of Alkyl Ethers with Diallyltriazinedione-Type Alkylating Agents (ATTACKs-R) Under Acid Catalysis
Hikaru Fujita, Rina Yamashita, Takanori Fujii, Kohei Yamada, Masanori Kitamura, Munetaka Kunishima
European Journal of Organic Chemistry 2019, (27), 4436–4446 (DOI: 10.1002/ejoc.201900607)
Phototriggered Active Alkyne Generation from Cyclopropenones with Visible Light-Responsive Photocatalysts
Kenji Mishiro, Takeshi Kimura, Taniyuki Furuyama, Munetaka Kunishima
Organic Letters 2019, 21 (11) 4101–4105 (DOI:10.1021/acs.orglett.9b01280)
金沢大学プレスリリースに掲載されました！
Development of a Storable Triazinone-Based Reagent for O-p-Methoxybenzylation under Mild Heating Conditions
Hikaru Fujita, Hiromitsu Terasaki, Satoshi Kakuyama, Kazuhito Hioki, Munetaka Kunishima
Organic Letters 2019, 21 (9), 3093–3097 (DOI: 10.1021/acs.orglett.9b00732)
2018
Phototriggered Ketone Formation from an Aminocyclopropenone and a Carboxylic Acid
Kenji Mishiro, Yuki Yushima, Munetaka Kunishima
The Journal of Organic Chemistry 2018, 83 (21), 13595–13603 (DOI: 10.1021/acs.joc.8b02250)
Cooperation of the Neutral and the Cationic Leaving Group Pathways in Acid-Catalyzed O-Benzylation of TriBOT
Hikaru Fujita , Naoko Hayakawa, Munetaka Kunishima
The Journal of Organic Chemistry 2018, 83 (17), 10684–10687 (DOI: 10.1021/acs.joc.8b01505)
Triazine-Based Cationic Leaving Group: Synergistic Driving Forces for Rapid Formation of Carbocation Species
Hikaru Fujita, Satoshi Kakuyama, Shuichi Fukuyoshi, Naoko Hayakawa, Akifumi Oda, Munetaka Kunishima
The Journal of Organic Chemistry 2018, 83 (8), 4568–4580 (DOI: 10.1021/acs.joc.8b00331)
Development of highly electron-deficient and less sterically-hindered phosphine ligands possessing 1,3,5-triazinyl groups
Kazumi Abe, Masanori Kitamura, Hikaru Fujita, Munetaka Kunishima
Molecular Catalysis 2018, 445, 87–93 (DOI: 10.1016/j.mcat.2017.11.008)
2017
Novel Alkylating Reagents Designed by the Characteristics of 1,3,5-Triazines
Munetaka Kunishima, Kohei Yamada, Hikaru Fujita, Masanori Kitamura
Journal of Synthetic Organic Chemistry, Japan 2017, 75 (10), 1023–1034 (DOI: 10.5059/yukigoseikyokaishi.75.1023)
Phototriggered Dehydration Condensation Using an Aminocyclopropenone
Kenji Mishiro, Yuki Yushima, Munetaka Kunishima
Organic letters 2017, 19 (18), 4912–4915 (DOI: 10.1021/acs.orglett.7b02383)
Study of O-Allylation using Triazine-based Reagents
Kohei Yamada, Naoko Hayakawa, Hikaru Fujita, Masanori Kitamura, Munetaka Kunishima
Chemical and Pharmaceutical Bulletin 2017, 65, 112–115 (DOI: 10.1248/cpb.c16-00744)
